Which is better to use for referencing single cells in excel: A1 or A:A / 1:1?

Is there a difference when using a cell reference and column / row reference when pointing to a single cell? Or is there a better way? Sample table below.

I have been using column / row reference for faster checking of formulas, using Show Formulas, but I do not know if it has an impact to memory and processing times for very large files.

Sample table (A/B or C/D?):

R\C  A        B        C        D
1    25       18       13       21
2    14       19       22       17
4    =A1+A2   =B1+B2   =1:1+2:2 =1:1+2:2
6    =A4      =B4      =4:4     =4:4

Thanks.