VBA: Checking optional parameters

I have two subs and want to pass values from one to the other.

Option Explicit

Sub Test()
    Call HandleInput(ActiveSheet.Range("A1:C4"), 4, 2)
End Sub

Sub HandleInput(rng As Range, rowNumber As Long, colNumber As Long)
    Debug.Print rng.Cells(rowNumber, colNumber).Value
End Sub

However, sometimes I want to apply the same routine over the same range, but with a different rownumber and a different colnumber. I could just call the sub again with the new values and right now that seems to be by far the easiest option, but I still want know if there's a smart way to handle it with optional parameters in HandleInput:

Sub HandleInput(rng As Range, rowNumber As Long, colNumber As Long, Optional rowNumber2 As Long, _
Optional colNumber2 As Long, Optional rowNumber3 As Long, Optional colNumber3 As Long)
   ...
End Sub

This made me wonder:

Can I somehow tell VBA that, if rowNumber2 is being provided, a value for colNumber2 needs to be passed as well? I know I could try it with IsMissing() and switching the data type to Variant:

Sub HandleInput(rng As Range, rowNumber As Long, colNumber As Long, Optional rowNumber2 As Variant, 
     _ Optional colNumber2 As Variant, Optional rowNumber3 As Variant, Optional colNumber3 As Variant)
          If Not IsMissing(rowNumber2) Then
              If IsMissing(colNumber2) Then
                   MsgBox "Please enter a value for colNumber2."
                   End
              End If
          End If
End Sub

This requires lots of if-Statements, also in the other direction, (If NOT IsMissing(colNumber2) Then). And it only gets worse if more than two variables should be tied together. Any calculation that I try as a workaround gives me an error ("Type mismatch") when one value is missing, for example I tried:

If IsError(rowNumber2 * colNumber2) Then
   MsgBox "Error, please supply both rowNumber2 and colNumber2"
End If

Is there a native functionality for this? The only solution I came up with is supplying default values that I know won't occur "naturally":

Sub HandleInput(rng As Range, rowNumber As Long, colNumber As Long, Optional rowNumber2 As Long = -100, _
Optional colNumber2 As Long = -100, Optional rowNumber3 As Long = -100, Optional colNumber3 As Long = -100)

     If rowNumber2 = -100 Or colNumber2 = -100 Then
        MsgBox "Please enter a value for both rowNumber2 and colNumber2."
        End
    End If
End Sub